HYDRATION QUANTIZATION OF RECEPTOR BINDING SITES














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Author
Introduction
Water
Protein Structure
Carboxypeptidase A
Alpha Chymotrypsin
Insulin
Ribonuclease A
Receptor Sites
Double-Helix B-DNA
References


AUTHOR

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Dr. Collins received his baccalaureate degree in Chemistry from Wayne University and his doctorate in Organic and Physical Chemistry from the University of Wisconsin. After employment at General Motors Research, Central Research at E. I. DuPont and Sterling Winthrop Research Institute, he accepted a position in 1958 as Associate Professor and Chairman of the Chemistry Department at Illinois Wesleyan University. Five years later, he returned to Sterling Winthrop Research Institute to direct Medicinal Chemical Research and then Technical Affairs for Sterling Drug Corporation until 1987 when he retired to devote full time to his driving interest in the ordering role of water in living cells.

He has a number of publications and patents to his credit and has had a synthetic reagent which he developed at Illinois Wesleyan University “The Collins Reagent” named after him. It was while he was employed at Sterling Winthrop Research Institute the first time that he found, in an extensive molecular model-building program, that the lengths of regulator and drug molecules corresponded to relatively distinct dimensional groups and then at Illinois Wesleyan that the dimensions corresponded to linear hydrogen-bonded elements of water molecules. To explain those observations, he developed the concepts of Transient Linear Hydration and Cubic Hydration Patterning and used them to develop membranal receptor models and new drugs at Sterling Winthrop Research Institute. Since he has been unable to get articles accepted for publication in reputable scientific journals, he has published the proposals in the three books listed below and in three web sites: www.linearwater.com, www.proteinhydration.com and www.molecularcreation.com.

Questions and comments can be addressed to the author at molepres2000@aol.com.

First Edition: "The Matrix of Life"

Published in 1991. ISBN 0-9629719-0-1

Library of Congress Catalog Card

Number 91-90379

Second Edition: “Water: The Vital Force of Life

Published in 2000. ISBN 0-9629719-2-8

Library of Congress Catalog Card

Number 00-90325

“Biomolecular Evolution from Water to the Molecules of Life”

Published in 2013. ISBN 978-1-6192742-1-1

Custom physical model building was performed with Framework Molecular Model Parts® (Prentice Hall, Englewood Cliffs, NJ 07632). Computerized Model Building and energy calculations were performed on Apple®, Macintosh® and Dell® computers using an Adobe® Illustrator® program to produce the graphics and available programs for energy calculations.

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